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Six novel lignanoids with complex structures from Sigesbeckia glabrescens Makino with their cytotoxic activities.
- Source :
-
Fitoterapia [Fitoterapia] 2021 Jan; Vol. 148, pp. 104799. Date of Electronic Publication: 2020 Dec 08. - Publication Year :
- 2021
-
Abstract
- Six new lignanoids, Glalignin A-E (1-5) and Glaneolignin A (6), together with four analogues, (+)-isolariciresinol (7), (+)-syringaresinol (8), dihydrodehydrodiconiferyl alcohol (9) and tribulusamide A (10), were obtained from the aerial parts of Sigesbeckia glabrescens Makino and also isolated for the first time from the Sigesbeckia genus. The structures of these compounds were elucidated by the interpretation of HRESIMS, 1D NMR, 2D NMR data and chemical evidence. The cytotoxic activities of the compounds were evaluated by testing their inhibition in several tumor cells using the MTT assay. New compound 2 and 5 displayed cytotoxicity against the human cancer cell lines human lung adenocarcinoma cells (A549) with IC <subscript>50</subscript> values of 32.89 ± 6.83 and 35.86 ± 6.83 μM.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- A549 Cells
Antineoplastic Agents, Phytogenic isolation & purification
China
HeLa Cells
Humans
Lignans isolation & purification
MCF-7 Cells
Molecular Structure
Phytochemicals isolation & purification
Phytochemicals pharmacology
Plant Components, Aerial chemistry
Antineoplastic Agents, Phytogenic pharmacology
Asteraceae chemistry
Lignans pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6971
- Volume :
- 148
- Database :
- MEDLINE
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 33301798
- Full Text :
- https://doi.org/10.1016/j.fitote.2020.104799