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Gene Regulation and Transcriptomics.
Gene Regulation and Transcriptomics.
- Source :
-
Current issues in molecular biology [Curr Issues Mol Biol] 2021; Vol. 42, pp. 223-266. Date of Electronic Publication: 2020 Dec 10. - Publication Year :
- 2021
-
Abstract
- Borrelia ( Borreliella ) burgdorferi , along with closely related species, is the etiologic agent of Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition from a vertebrate host to a tick vector and transmission from a tick vector to a vertebrate host. To adapt to its environment and persist in each phase of its enzootic cycle, B. burgdorferi wields three systems to regulate the expression of genes: the RpoN-RpoS alternative sigma factor cascade, the Hk1/Rrp1 two-component system and its product c-di-GMP, and the stringent response mediated by Rel <subscript>Bbu</subscript> and DksA. These regulatory systems respond to enzootic phase-specific signals and are controlled or fine- tuned by transcription factors, including BosR and BadR, as well as small RNAs, including DsrABb and Bb6S RNA. In addition, several other DNA-binding and RNA-binding proteins have been identified, although their functions have not all been defined. Global changes in gene expression revealed by high-throughput transcriptomic studies have elucidated various regulons, albeit technical obstacles have mostly limited this experimental approach to cultivated spirochetes. Regardless, we know that the spirochete, which carries a relatively small genome, regulates the expression of a considerable number of genes required for the transitions between the tick vector and the vertebrate host as well as the adaptation to each.
- Subjects :
- Adaptation, Physiological
Animals
Arthropod Vectors microbiology
Genes, Bacterial
Host-Pathogen Interactions
Humans
Lyme Disease transmission
Ticks microbiology
Borrelia burgdorferi genetics
Gene Expression Profiling
Gene Expression Regulation, Bacterial
Lyme Disease microbiology
Transcriptome
Subjects
Details
- Language :
- English
- ISSN :
- 1467-3045
- Volume :
- 42
- Database :
- MEDLINE
- Journal :
- Current issues in molecular biology
- Publication Type :
- Academic Journal
- Accession number :
- 33300497
- Full Text :
- https://doi.org/10.21775/cimb.042.223