Back to Search
Start Over
Acute Exposure to Environmental Tobacco Smoke: A Controlled Study in Adults with Asthma.
- Source :
-
Respiration; international review of thoracic diseases [Respiration] 2020 Dec 09, pp. 1-8. Date of Electronic Publication: 2020 Dec 09. - Publication Year :
- 2020
- Publisher :
- Ahead of Print
-
Abstract
- Background: Short-term, indoor exposure to environmental tobacco smoke (ETS) is still highly prevalent; however, little is known about the acute lung response in adult asthma.<br />Objectives: We investigated whether acute, experimental ETS exposure influences symptoms, lung function, and inflammatory parameters.<br />Methods: Human subjects with asthma (n = 23) were exposed for 180 min to either room air or ETS at 250, 450, or 850 µg/m3. Respiratory symptoms, lung function, and exhaled nitric oxide (FeNO) were measured. Additionally, blood samples were analyzed for pro- and anti-inflammatory cytokines.<br />Results: Humans with asthma demonstrate an increase in respiratory symptoms at all levels of ETS exposure, while the forced expiratory volume in 1 s (FEV1) and FeNO decrease with increasing ETS. The anti-inflammatory cytokine interleukin (IL)-10 increases at intermediate ETS concentrations, whereas tumor necrosis factor (TNF)-α and IL-8 increase only at the highest ETS concentration.<br />Conclusion: Following 180 min of acute, experimental ETS exposure, we observed a significant increase in respiratory symptoms, a decrease in lung function, and an increase in inflammatory cytokines, indicating an acute lung response in asthma.<br /> (© 2020 S. Karger AG, Basel.)
Details
- Language :
- English
- ISSN :
- 1423-0356
- Database :
- MEDLINE
- Journal :
- Respiration; international review of thoracic diseases
- Publication Type :
- Academic Journal
- Accession number :
- 33296904
- Full Text :
- https://doi.org/10.1159/000508397