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The main protease and RNA-dependent RNA polymerase are two prime targets for SARS-CoV-2.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 29; Vol. 538, pp. 63-71. Date of Electronic Publication: 2020 Nov 21. - Publication Year :
- 2021
-
Abstract
- The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health crisis. It is particularly urgent to develop clinically effective therapies to contain the pandemic. The main protease (M <superscript>pro</superscript> ) and the RNA-dependent RNA polymerase (RdRP), which are responsible for the viral polyprotein proteolytic process and viral genome replication and transcription, respectively, are two attractive drug targets for SARS-CoV-2. This review summarizes up-to-date progress in the structural and pharmacological aspects of those two key targets above. Different classes of inhibitors individually targeting M <superscript>pro</superscript> and RdRP are discussed, which could promote drug development to treat SARS-CoV-2 infection.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Antiviral Agents pharmacology
Coronavirus Protease Inhibitors pharmacology
Drug Design
Enzyme Inhibitors pharmacology
Humans
Protein Conformation
SARS-CoV-2 drug effects
Antiviral Agents chemistry
Coronavirus 3C Proteases antagonists & inhibitors
Coronavirus 3C Proteases chemistry
Coronavirus Protease Inhibitors chemistry
Coronavirus RNA-Dependent RNA Polymerase antagonists & inhibitors
Coronavirus RNA-Dependent RNA Polymerase chemistry
Enzyme Inhibitors chemistry
SARS-CoV-2 enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 538
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 33288200
- Full Text :
- https://doi.org/10.1016/j.bbrc.2020.10.091