Back to Search
Start Over
Dietary Lactate Supplementation Protects against Obesity by Promoting Adipose Browning in Mice.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2020 Dec 16; Vol. 68 (50), pp. 14841-14849. Date of Electronic Publication: 2020 Dec 07. - Publication Year :
- 2020
-
Abstract
- Yogurt has been widely used in weight-loss foods to prevent obesity, but its molecular nature remains unclear. Lactate is a major ingredient of yogurt, while its cognate cell surface receptor GPR81 is highly expressed in adipose tissues in mammals. Here we hypothesized that dietary lactate supplementation might activate GPR81 to promote adipose browning. Studying mouse models, we observed that GPR81 was substantially lowered in adipose tissue of obese mice compared with that for lean ones, whereas its expression was markedly up-regulated by a β3-adrenergic receptor (β3-AR) agonist. The deficiency of GPR81 greatly attenuated experimental adipose browning and thermogenesis. Importantly, oral administration of lactate effectively induced adipose browning, enhanced thermogenesis, improved dyslipidemia, and protected mice against high-fat-diet-induced obesity. Mechanistically, p38 mitogen-activated protein kinase might serve as a key downstream effect or of GPR81. Collectively, our findings revealed a critical role of GPR81 in adipose browning and provided a new insight into obesity management by modulating lactate-GPR81 signaling axis.
- Subjects :
- Adipose Tissue, Brown drug effects
Animals
Energy Metabolism drug effects
Humans
Lactic Acid metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Obese
Obesity genetics
Obesity metabolism
Obesity physiopathology
Receptors, Adrenergic, beta-3 genetics
Receptors, Adrenergic, beta-3 metabolism
Receptors, G-Protein-Coupled genetics
Receptors, G-Protein-Coupled metabolism
Adipose Tissue, Brown metabolism
Dietary Supplements analysis
Obesity drug therapy
Protective Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 68
- Issue :
- 50
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 33284607
- Full Text :
- https://doi.org/10.1021/acs.jafc.0c05899