Simple Kinetic Models in Molecular Chronobiology.

Circadian rhythms are constituted by a complex dynamical system with intertwined feedback loops, molecular switches, and self-sustained oscillations. Mathematical modeling supports understanding available heterogeneous kinetic data, highlights basic mechanisms, and can guide experimental research. Here, we introduce the basic steps from a biological question to simple models providing insight into gene-regulatory mechanisms. We illustrate the general approach by three examples: modeling decay processes, clock-controlled genes, and self-sustained oscillations.