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Evaluating the effect of ozone in UV induced skin damage.

Authors :: Ferrara F
Pambianchi E
Woodby B
Messano N
Therrien JP
Pecorelli A
Canella R
Valacchi G
Source :: Toxicology letters [Toxicol Lett] 2021 Mar 01; Vol. 338, pp. 40-50. Date of Electronic Publication: 2020 Dec 03.
Publication Year :: 2021
Abstract: Air pollution represents one of the main risks for both environment and human health. The rapid urbanization has been leading to a continuous release of harmful manmade substances into the atmosphere which are associated to the exacerbation of several pathologies. The skin is the main barrier of our body against the external environment and it is the main target for the outdoor stressors. Among the pollutants, Ozone (O <subscript>3</subscript> ) is one of the most toxic, able to initiate oxidative reactions and activate inflammatory response, leading to the onset of several skin conditions. Moreover, skin is daily subjected to the activity of Ultraviolet Radiation which are well known to induce harmful cutaneous effects including skin aging and sunburn. Even though both UV and O <subscript>3</subscript> are able to affect the skin homeostasis, very few studies have investigated their possible additive effect. Therefore, in this study we evaluated the effect of the combined exposure of O <subscript>3</subscript> and UV in inducing skin damage, by exposing human skin explants to UV alone or in combination with O <subscript>3</subscript> for 4-days. Markers related to inflammation, redox homeostasis and tissue structure were analyzed. Our results demonstrated that O <subscript>3</subscript> is able to amplify the UV induced skin oxinflammation markers.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)