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Synovial fluid presepsin as a novel biomarker for the rapid differential diagnosis of native joint septic arthritis from crystal arthritis.
- Source :
-
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Jan; Vol. 102, pp. 472-477. Date of Electronic Publication: 2020 Dec 02. - Publication Year :
- 2021
-
Abstract
- Objective: To investigate whether presepsin can be used as a novel biomarker to differentiate between native joint septic arthritis (NJSA) and crystal arthritis (CA).<br />Methods: This study included 75 patients diagnosed with either NJSA (n = 21) or CA (n = 54). Presepsin in synovial fluid and blood, C-reactive protein, and procalcitonin were measured and compared between the NJSA and CA groups. Receiver operating characteristic (ROC) curve analyses were performed to differentiate between the two groups.<br />Results: Synovial fluid and blood presepsin were significantly higher in the NJSA group than in the CA group (p < 0.0001 and p < 0.01, respectively). The area under the ROC curve for synovial fluid presepsin in the NJSA group compared with the CA group was 0.93 (sensitivity 85.7%, specificity 85.2%, positive predictive value 69.2%, negative predictive value 93.9%, positive likelihood ratio 5.79, negative likelihood ratio 0.17). Among the tests, synovial fluid presepsin was the most accurate.<br />Conclusions: Measurement of synovial fluid presepsin is reliable for the early diagnosis of NJSA, and synovial fluid presepsin could be used as a novel biomarker for differentiating between NJSA and CA.<br /> (Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Arthritis, Infectious metabolism
Arthritis, Infectious therapy
Arthrocentesis
C-Reactive Protein analysis
Cross-Sectional Studies
Crystal Arthropathies metabolism
Crystal Arthropathies therapy
Diagnosis, Differential
Early Diagnosis
Female
Humans
Male
Procalcitonin analysis
ROC Curve
Sensitivity and Specificity
Synovial Fluid metabolism
Arthritis, Infectious diagnosis
Biomarkers analysis
Crystal Arthropathies diagnosis
Lipopolysaccharide Receptors analysis
Peptide Fragments analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3511
- Volume :
- 102
- Database :
- MEDLINE
- Journal :
- International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 33278715
- Full Text :
- https://doi.org/10.1016/j.ijid.2020.10.030