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The effect of diclofenac sodium intoxication on the cardiovascular system in rats.
- Source :
-
The American journal of emergency medicine [Am J Emerg Med] 2021 Aug; Vol. 46, pp. 560-566. Date of Electronic Publication: 2020 Nov 13. - Publication Year :
- 2021
-
Abstract
- Objectives: Diclofenac sodium (DS) is a widely used nonsteroidal anti-inflammatory drug. Although its high doses are known to cause toxic effects in many tissues including liver and kidney, the effects on the cardiovascular system (CVS) have not been fully elucidated yet. Therefore, this study aimed to investigate the effect of DS on CVS.<br />Methods: The Control group did not receive medication; however, a single dose of 240 mg/kg DS was administered orally to the DS group. Electrocardiography (ECG) measurements were performed in all animals before (0thhour) and after (1st,6th,12th,24thhour) intoxication. After 24 h, All animals were sacrificed. Biochemical (malondialdehyde [MDA], and glutathione (GSH), Apelin, Elabela, Meteorin, Endoglin, Keap1, and Nrf2) and histopathological analyzes were performed on heart tissue samples.<br />Results: ECG results showed that there was a statistically significant increase in QTc, QRS, and heart rate at the 12th and 24th hours in the DS group. The biochemical analysis showed that GSH, Apelin, Keap1, and NRF2 values decreased significantly while Meteorin and Endoglin levels increased in the DS group. When histopathological results were evaluated, distinct lesions were observed in the DS group.<br />Conclusion: In conclusion, high doses of DS intake can cause adverse effects on and damage to CVS.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no competing interests.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Apelin drug effects
Apelin metabolism
Cardiovascular System drug effects
Electrocardiography
Endoglin drug effects
Endoglin metabolism
Glutathione drug effects
Glutathione metabolism
Kelch-Like ECH-Associated Protein 1 drug effects
Kelch-Like ECH-Associated Protein 1 metabolism
Malondialdehyde metabolism
Myocardium pathology
NF-E2-Related Factor 2 drug effects
NF-E2-Related Factor 2 metabolism
Nerve Tissue Proteins drug effects
Nerve Tissue Proteins metabolism
Peptide Hormones drug effects
Peptide Hormones metabolism
Rats
Anti-Inflammatory Agents, Non-Steroidal toxicity
Diclofenac toxicity
Heart drug effects
Heart Rate drug effects
Myocardium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8171
- Volume :
- 46
- Database :
- MEDLINE
- Journal :
- The American journal of emergency medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33272872
- Full Text :
- https://doi.org/10.1016/j.ajem.2020.11.022