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Correlation between corin, N-terminal pro-atrial natriuretic peptide and neonatal adverse prognostic in hypertensive disorders of pregnancy.
- Source :
-
Pregnancy hypertension [Pregnancy Hypertens] 2021 Mar; Vol. 23, pp. 73-78. Date of Electronic Publication: 2020 Nov 25. - Publication Year :
- 2021
-
Abstract
- Introduction: Atrial natriuretic peptide (ANP) regulates water-salt balance and blood pressure by promoting renal sodium and water excretion.<br />Objective: Our study was to investigate plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) and corin in hypertensive disorders of pregnancy (HDP) patients. Furthermore, the relationship between corin/NT-proANP and neonatal adverse prognosis were evaluated.<br />Methods: Seventy-seven HDP patients and forty-eight normotensive women as control group were recruited. Clinical characteristic and plasma were collected. Plasma NT-proANP and corin were determined by ELISA. Gestational age, neonatal weight and APGAR scores were recorded. Statistical analysis was conducted.<br />Results: NT-proANP and corin were significantly increased in HDP group compared with that of control (P < 0.05). NT-proANP and corin were significantly elevated in HDP patients who suffered from premature delivery (P < 0.05). Both NT-proANP and corin were negatively associated with delivery time, neonatal weight and APGAR scores in HDP group. Multiple regressions demonstrated that NT-proANP and corin were independent risk factor of delivery time, neonatal weight and APGAR scores.<br />Conclusions: Plasma NT-proANP and corin were significantly increased in HDP. NT-proANP and corin were associated with neonatal adverse events in HDP patients. Thus, NT-proANP and corin may become new biomarkers for evaluating severity of pregnancy and neonatal adverse events in HDP patients.<br /> (Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Apgar Score
Biomarkers blood
Birth Weight
Case-Control Studies
Cross-Sectional Studies
Female
Humans
Hypertension, Pregnancy-Induced blood
Infant, Newborn
Pregnancy
Premature Birth blood
Atrial Natriuretic Factor blood
Hypertension, Pregnancy-Induced epidemiology
Premature Birth epidemiology
Serine Endopeptidases blood
Subjects
Details
- Language :
- English
- ISSN :
- 2210-7797
- Volume :
- 23
- Database :
- MEDLINE
- Journal :
- Pregnancy hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 33264706
- Full Text :
- https://doi.org/10.1016/j.preghy.2020.11.007