Prenatal exposure to preeclampsia as a risk factor for long-term endocrine morbidity of the offspring.

Objective : To analyze preeclampsia as a risk factor for pediatric endocrine disease. Study Design : A population-based cohort analysis comparing the risk of endocrine morbidity of children born between 1991-2014 to mothers with and without preeclampsia. Results : The study included 253,808 deliveries. Exposed offspring had significantly more endocrine hospitalizations (0.7% vs 0.4%; p  < 0.001), specifically obesity (0.4% vs 0.2%,  p  < 0.001). While controlling for confounders, the exposed offspring had significantly more endocrine morbidity (OR 1.433 95% CI 1.115-1.841  p  = 0.005). Conclusion : Preeclampsia is an independent risk factor for long-term endocrine disease of the offspring, specifically obesity.