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Cerebrospinal fluid microscopy as an index for predicting the prognosis of cryptococcal meningitis patients with and without HIV.
- Source :
-
Future microbiology [Future Microbiol] 2020 Nov; Vol. 15, pp. 1645-1652. Date of Electronic Publication: 2020 Nov 30. - Publication Year :
- 2020
-
Abstract
- Aim: To evaluate the clinical data and quantitative cerebrospinal fluid for associations with the outcome of cryptococcal meningitis (CM) patients in the hospital. Patients & methods: We retrospectively analyzed a total of 139 CM patients comprising 108 without HIV and 31 with HIV admitted in a Jiang Xi hospital. Resμlts: We found that CM patients with the high fungal burden (≥10 yeasts/μl) (26.3%) had a worse prognosis than those with the low fungal burden (<10 yeasts/μl). (4.9%) (p = 0.0007 <0.05). Conclusion: In CM patients, a fungal burden of 10 yeasts/μl in the first cerebrospinal fluid test may be used as an indicator of patient prognosis, and we can personalize patients' treatment based on the fungal burden to improve prognosis.
- Subjects :
- AIDS-Related Opportunistic Infections microbiology
AIDS-Related Opportunistic Infections mortality
Adolescent
Adult
Aged
Aged, 80 and over
Cerebrospinal Fluid chemistry
Cerebrospinal Fluid microbiology
Child
Child, Preschool
Cryptococcus neoformans genetics
Cryptococcus neoformans isolation & purification
Cryptococcus neoformans physiology
Female
Humans
Male
Meningitis, Cryptococcal etiology
Meningitis, Cryptococcal microbiology
Meningitis, Cryptococcal mortality
Microscopy
Middle Aged
Prognosis
Retrospective Studies
Young Adult
AIDS-Related Opportunistic Infections cerebrospinal fluid
HIV Infections complications
Meningitis, Cryptococcal cerebrospinal fluid
Subjects
Details
- Language :
- English
- ISSN :
- 1746-0921
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Future microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 33251866
- Full Text :
- https://doi.org/10.2217/fmb-2020-0086