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Bone phenotypes in rheumatology - there is more to bone than just bone.

Authors :
Thudium CS
Nielsen SH
Sardar S
Mobasheri A
van Spil WE
Lories R
Henriksen K
Bay-Jensen AC
Karsdal MA
Source :
BMC musculoskeletal disorders [BMC Musculoskelet Disord] 2020 Nov 28; Vol. 21 (1), pp. 789. Date of Electronic Publication: 2020 Nov 28.
Publication Year :
2020

Abstract

Osteoarthritis, rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, all have one clear common denominator; an altered turnover of bone. However, this may be more complex than a simple change in bone matrix and mineral turnover. While these diseases share a common tissue axis, their manifestations in the area of pathology are highly diverse, ranging from sclerosis to erosion of bone in different regions. The management of these diseases will benefit from a deeper understanding of the local versus systemic effects, the relation to the equilibrium of the bone balance (i.e., bone formation versus bone resorption), and the physiological and pathophysiological phenotypes of the cells involved (e.g., osteoblasts, osteoclasts, osteocytes and chondrocytes). For example, the process of endochondral bone formation in chondrocytes occurs exists during skeletal development and healthy conditions, but also in pathological conditions. This review focuses on the complex molecular and cellular taxonomy of bone in the context of rheumatological diseases that alter bone matrix composition and maintenance, giving rise to different bone turnover phenotypes, and how biomarkers (biochemical markers) can be applied to potentially describe specific bone phenotypic tissue profiles.

Details

Language :
English
ISSN :
1471-2474
Volume :
21
Issue :
1
Database :
MEDLINE
Journal :
BMC musculoskeletal disorders
Publication Type :
Academic Journal
Accession number :
33248451
Full Text :
https://doi.org/10.1186/s12891-020-03804-2