Back to Search
Start Over
The Population-Specific Impact of Neandertal Introgression on Human Disease.
- Source :
-
Genome biology and evolution [Genome Biol Evol] 2021 Jan 07; Vol. 13 (1). - Publication Year :
- 2021
-
Abstract
- Since the discovery of admixture between modern humans and Neandertals, multiple studies investigated the effect of Neandertal-derived DNA on human disease and nondisease phenotypes. These studies have linked Neandertal ancestry to skin- and hair-related phenotypes, immunity, neurological, and behavioral traits. However, these inferences have so far been limited to cohorts with participants of European ancestry. Here, I analyze summary statistics from 40 disease GWAS (genome-wide association study) cohorts of ∼212,000 individuals provided by the Biobank Japan Project for phenotypic effects of Neandertal DNA. I show that Neandertal DNA is associated with autoimmune diseases, prostate cancer and type 2 diabetes. Many of these disease associations are linked to population-specific Neandertal DNA, highlighting the importance of studying a wider range of ancestries to characterize the phenotypic legacy of Neandertals in people today.<br /> (© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)
Details
- Language :
- English
- ISSN :
- 1759-6653
- Volume :
- 13
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Genome biology and evolution
- Publication Type :
- Academic Journal
- Accession number :
- 33247712
- Full Text :
- https://doi.org/10.1093/gbe/evaa250