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Tachyplesin induces apoptosis in non-small cell lung cancer cells and enhances the chemosensitivity of A549/DDP cells to cisplatin by activating Fas and necroptosis pathway.
- Source :
-
Chemical biology & drug design [Chem Biol Drug Des] 2021 Apr; Vol. 97 (4), pp. 809-820. Date of Electronic Publication: 2020 Dec 05. - Publication Year :
- 2021
-
Abstract
- Cisplatin has strong broad-spectrum anticancer activity and is one of the most effective anticancer drugs currently used. The clinical application of cisplatin has led to the resistance of cancer cells to cisplatin. Tachyplesin is an active, natural marine peptide with antitumour activity. In the present study, we investigated whether tachyplesin can be used in non-small cell lung cancer (NSCLC) A549 and H460 cells as well as the cisplatin-resistant human A549/DDP NSCLC cell line. The results revealed that tachyplesin treatment significantly inhibited proliferation and induced apoptosis in A549 and H460 cells and the combination of tachyplesin and cisplatin significantly suppressed migration and improved sensitivity to cisplatin in A549/DDP cells. Further mechanistic examination revealed that tachyplesin induced apoptosis in A549/DDP cells by increasing Fas, FasL and p-RIPK1 levels. These results indicated that tachyplesin induces lung cancer death by activating the Fas, mitochondrial and necroptosis pathways. Tachyplesin could be developed as a candidate drug for cisplatin-resistant NSCLC.<br /> (© 2020 John Wiley & Sons A/S.)
- Subjects :
- Antineoplastic Agents pharmacology
Carcinoma, Non-Small-Cell Lung metabolism
Carcinoma, Non-Small-Cell Lung pathology
Cell Line, Tumor
Cell Movement drug effects
Cisplatin pharmacology
Humans
Lung Neoplasms metabolism
Lung Neoplasms pathology
Membrane Potential, Mitochondrial drug effects
Necroptosis drug effects
Up-Regulation drug effects
fas Receptor metabolism
Antimicrobial Cationic Peptides pharmacology
Apoptosis drug effects
DNA-Binding Proteins pharmacology
Drug Resistance, Neoplasm drug effects
Peptides, Cyclic pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1747-0285
- Volume :
- 97
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Chemical biology & drug design
- Publication Type :
- Academic Journal
- Accession number :
- 33245189
- Full Text :
- https://doi.org/10.1111/cbdd.13810