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Pulmonary disease caused by a newly identified mycobacterium: Mycolicibacterium toneyamachuris: a case report.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2020 Nov 25; Vol. 20 (1), pp. 888. Date of Electronic Publication: 2020 Nov 25. - Publication Year :
- 2020
-
Abstract
- Background: Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is becoming a significant health burden. Recent advances in analysis techniques have allowed the accurate identification of previously unknown NTM species. Here, we report a case of NTM-PD caused by a newly identified mycobacteria in an immunocompetent patient.<br />Case Presentation: A 44-year-old woman was referred to our hospital due to the frequent aggravation of her chronic respiratory symptoms, with NTM-PD-compatible computed tomography findings. Unidentified mycobacterium was repeatedly isolated from respiratory specimens and we diagnosed her as NTM-PD of unidentified mycobacterium. Subsequent whole-genome analysis revealed that the unidentified mycobacterium was a novel mycobacterium genetically close to Mycolicibacterium mucogenicum. We started combination therapy with clarithromycin, moxifloxacin, amikacin, and imipenem/cilastatin, referring to drug sensitivity test results and observed its effect on M. mucogenicum infection. Her symptoms and radiological findings improved significantly.<br />Conclusion: We report a case of NTM-PD caused by a newly identified mycobacteria, Mycolicibacterium toneyamachuris, genetically close to M. mucogenicum. This pathogenic mycobacterium showed different characteristics from M. mucogenicum about clinical presentation and drug sensitivity. The clinical application of genomic sequencing will advance the identification and classification of pathogenic NTM species, and enhance our understanding of mycobacterial diseases.
- Subjects :
- Adult
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents therapeutic use
Diagnostic Tests, Routine
Female
Humans
Lung Diseases microbiology
Microbial Sensitivity Tests
Multilocus Sequence Typing methods
Mycobacterium Infections, Nontuberculous drug therapy
Mycobacterium Infections, Nontuberculous microbiology
Nontuberculous Mycobacteria drug effects
Treatment Outcome
Whole Genome Sequencing methods
Lung Diseases diagnosis
Mycobacterium Infections, Nontuberculous diagnosis
Nontuberculous Mycobacteria genetics
Nontuberculous Mycobacteria isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 20
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 33238934
- Full Text :
- https://doi.org/10.1186/s12879-020-05626-y