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Hypoxia-responsive nanogel as IL-12 carrier for anti-cancer therapy.
- Source :
-
Nanotechnology [Nanotechnology] 2021 Feb 26; Vol. 32 (9), pp. 095107. - Publication Year :
- 2021
-
Abstract
- In the past two decades, protein drugs have evolved to become the most successful and important strategy in cancer therapy. However, systematical administration of protein drugs may cause serious side effects. In order to prepare a new promising hydrophilic drugs carrier, we constructed a PEGylated hyaluronic acid nanogel (NI-MAHA-PEG nanogel) with hypoxia and enzymatic responsiveness, which can selectively release hydrophilic drugs interleukin-12 (IL-12) on demand in a tumor microenvironment. We observed that release of IL-12 from nanogels by hypoxia-responsive stimulation, nanogels have anti-tumor effects on melanoma. Compared with physiological conditions, the IL-12 release rate has achieved remarkable growth under hypoxic conditions. Similarly, the drug release rate increased significantly with the addition of 500 U ml <superscript>-1</superscript> hyaluronidase. We provide a novel strategy to allow efficient delivery, on-demand release, and enhanced access of proteins to hypoxic tumor regions. The rational design of this nanogels drug delivery system can further explore the use of various drugs to treat many cancers.
- Subjects :
- Animals
Cell Hypoxia
Cell Line, Tumor
Cell Proliferation drug effects
Cell Survival drug effects
Female
Interleukin-12 chemistry
Interleukin-12 pharmacology
Mice
Nanogels
Polyethylene Glycols chemistry
Xenograft Model Antitumor Assays
Hyaluronic Acid chemistry
Interleukin-12 administration & dosage
Melanoma, Experimental drug therapy
Skin Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1361-6528
- Volume :
- 32
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Nanotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 33238258
- Full Text :
- https://doi.org/10.1088/1361-6528/abcdcc