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Application of sulfoximines in medicinal chemistry from 2013 to 2020.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 01; Vol. 209, pp. 112885. Date of Electronic Publication: 2020 Sep 28. - Publication Year :
- 2021
-
Abstract
- In recent years, interest in sulfoximine chemistry has been greatly increased. For example, at least three sulfoximine containing drugs BAY 1143572, BAY 1251152 and AZD6738 have entered the clinic. Despite the increasing interest in sulfoximines and their chemistry, the routine application of this structure in drug discovery is still hampered due to limited experience in physicochemical and in vitro parameters of sulfoximines. Therefore, we reviewed all relevant articles from 2013 to the present in terms of potency and pharmacokinetic properties in order to support the addition of the sulfoximine component to the toolbox of medicinal chemists.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2020. Published by Elsevier Masson SAS.)
- Subjects :
- Animals
Chemistry, Pharmaceutical
Humans
Indoles
Morpholines
Pyrimidines chemistry
Pyrimidines pharmacokinetics
Pyrimidines pharmacology
Sulfonamides chemistry
Sulfonamides pharmacokinetics
Sulfonamides pharmacology
Sulfoxides chemistry
Sulfoxides pharmacokinetics
Sulfoxides pharmacology
Sulfur Compounds pharmacokinetics
Sulfur Compounds pharmacology
Triazines chemistry
Triazines pharmacokinetics
Triazines pharmacology
Drug Development
Drug Discovery
Sulfur Compounds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 209
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 33227576
- Full Text :
- https://doi.org/10.1016/j.ejmech.2020.112885