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Circulating and local nuclear expression of survivin and fibulin-3 genes in discriminating benign from malignant respiratory diseases: correlation analysis.
- Source :
-
Bioscience reports [Biosci Rep] 2021 Jan 29; Vol. 41 (1). - Publication Year :
- 2021
-
Abstract
- Survivin is an inhibitor of apoptosis as well as a promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein that displays potential for tumor suppression or propagation. The present study aimed to validate the expression levels of survivin and fibulin-3 in benign and malignant respiratory diseases. This case-control study included 219 patients categorized into five groups. Group A included 63 patients with lung cancer, group B included 63 patients with various benign lung diseases, group D included 45 patients with malignant pleural mesothelioma (MPM), and group E included 48 patients with various benign pleural diseases. Group C included 60 healthy individuals (control group). Serum survivin and fibulin-3 levels were measured by ELISA, whereas their nuclear expressions in the lung and pleura were assessed via Western blot analysis. The results showed significantly higher survivin serum levels and significantly lower fibulin-3 levels in group A compared with in group B and controls (P<0.001). There were significantly higher serum levels of survivin and fibulin-3 in group D compared with in group E and controls (P<0.001), consistent with observed nuclear survivin and fibulin-3 expression levels. Fibulin-3 was determined to have higher value than survivin in discriminating lung cancer from MPM (P<0.05). Survivin and fibulin-3 could be useful diagnostic markers for lung and pleural cancers, and fibulin-3 expression was particularly useful in differentiating lung cancer from MPM.<br /> (© 2020 The Author(s).)
- Subjects :
- Biomarkers metabolism
Blotting, Western
Case-Control Studies
Diagnosis, Differential
Enzyme-Linked Immunosorbent Assay
Extracellular Matrix Proteins metabolism
Female
Humans
Male
Mesothelioma, Malignant diagnosis
Mesothelioma, Malignant metabolism
Middle Aged
Pleural Diseases diagnosis
Pleural Diseases metabolism
Survivin metabolism
Extracellular Matrix Proteins genetics
Mesothelioma, Malignant genetics
Pleural Diseases genetics
Survivin genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1573-4935
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioscience reports
- Publication Type :
- Academic Journal
- Accession number :
- 33226065
- Full Text :
- https://doi.org/10.1042/BSR20203097