Two new indole-diterpenoids from the marine-derived fungus Penicillium sp. KFD28.

Authors :: Chen MY
Xie QY
Kong FD
Ma QY
Zhou LM
Yuan JZ
Dai HF
Wu YG
Zhao YX
Source :: Journal of Asian natural products research [J Asian Nat Prod Res] 2021 Nov; Vol. 23 (11), pp. 1030-1036. Date of Electronic Publication: 2020 Nov 23.
Publication Year :: 2021
Abstract: Two new compounds named epipaxilline ( 1 ) and penerpene J ( 2 ) were isolated from the marine-derived fungus Penicillium sp. KFD28. Their structures including absolute configurations were determined on the basis of spectroscopic methods and ECD analysis. Compounds 1 and 2 showed inhibitory activities against PTP1B with IC <subscript>50</subscript> values of 31.5 and 9.5 μM, respectively, and compound 2 also showed inhibitory activities against TCPTP with IC <subscript>50</subscript> value of 14.7 μM.

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