Synthesis of potentially new schiff bases of N -substituted-2-quinolonylacetohydrazides as anti-COVID-19 agents.

Authors :: Alshammari MB
Ramadan M
Aly AA
El-Sheref EM
Bakht MA
Ibrahim MAA
Shawky AM
Source :: Journal of molecular structure [J Mol Struct] 2021 Apr 15; Vol. 1230, pp. 129649. Date of Electronic Publication: 2020 Nov 16.
Publication Year :: 2021
Abstract: We report herein a new series of synthesized N -substituted-2-quinolonylacetohydrazides aiming to evaluate their activity towards SARS-CoV-2. The structures of the obtained products were fully confirmed by NMR, mass, IR spectra and elemental analysis as well. Molecular docking calculations showed that most of the tested compounds possessed good binding affinity to the SARS-CoV-2 main protease (M <superscript>pro</superscript> ) comparable to Remdesivir .<br />Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (© 2020 Elsevier B.V. All rights reserved.)

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