The Problem of Neurovascular Uncoupling.

Authors :: Agarwal S
Sair HI
Pillai JJ
Source :: Neuroimaging clinics of North America [Neuroimaging Clin N Am] 2021 Feb; Vol. 31 (1), pp. 53-67. Date of Electronic Publication: 2020 Oct 29.
Publication Year :: 2021
Abstract: Neurovascular uncoupling (NVU) is one of the most important confounds of blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMR imaging) in the setting of focal brain lesions such as brain tumors. This article reviews the assessment of NVU related to focal brain lesions with emphasis on the use of cerebrovascular reactivity mapping measurement methods and resting state BOLD fMR imaging metrics in the detection of NVU, as well as the use of amplitude of low-frequency fluctuation metrics to mitigate the effects of NVU on clinical fMR imaging activation.<br />Competing Interests: Disclosure The authors report no financial conflicts of interest.<br /> (Copyright © 2020 Elsevier Inc. All rights reserved.)