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Risk for Hepatitis E Virus Transmission by Solvent/Detergent-Treated Plasma.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2020 Dec; Vol. 26 (12), pp. 2881-2886. - Publication Year :
- 2020
-
Abstract
- Hepatitis E has emerged as a major transfusion-transmitted infectious risk. Two recipients of plasma from 2 lots (A and B) of pooled solvent/detergent-treated plasma were found to be infected by hepatitis E virus (HEV) that was determined to have been transmitted by the solvent/detergent-treated plasma. HEV RNA viral loads were 433 IU in lot A and 55 IU in lot B. Retrospective studies found that 100% (13/13) of evaluable lot A recipients versus 18% (3/17) of evaluable lot B recipients had been infected by HEV (p<0.001), albeit not necessarily at time of transfusion. Among evaluable recipients, 86% with a transfused HEV RNA load >50,000 IU were infected, most likely by the HEV-containing solvent/detergent-treated plasma, versus only 7% with a transfused HEV RNA load <50,000 IU (p<0.001). Overall, solvent/detergent-treated plasma might harbor HEV. Such an occurrence might result in a dose-dependent risk for transfusion-transmitted hepatitis E.
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 26
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 33219652
- Full Text :
- https://doi.org/10.3201/eid2612.191482