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Prenatal diagnosis and management of monozygotic twins discordant for severe fetal abnormalities.
- Source :
-
Taiwanese journal of obstetrics & gynecology [Taiwan J Obstet Gynecol] 2020 Nov; Vol. 59 (6), pp. 945-947. - Publication Year :
- 2020
-
Abstract
- Objective: We present prenatal diagnosis and management of monozygotic (MZ) twins discordant for severe fetal abnormalities.<br />Case Report: A 36-year-old woman underwent amniocentesis at 18 weeks of gestation because of advanced maternal age, and hydrops fetalis, a giant cystic hygroma of 5 × 3.5 cm and left hydronephrosis in a co-twin. The other co-twin was structurally normal. Amniocentesis revealed a karyotype of 46,XY in both co-twins. Simultaneous polymorphic DNA marker analysis using the DNAs extracted from maternal blood and uncultured amniocytes confirmed MZ twinning. The woman underwent a successful selective fetal reduction by radiofrequency ablation at 22 weeks of gestation. At 28 weeks of gestation, premature rupture of membranes occurred, and a 1280-g normal male baby and a 275-g dead malformed co-twin were delivered. The normal co-twin was phenotypically normal and was doing well at age seven weeks.<br />Conclusions: Prenatal diagnosis of MZ twins discordant for structural abnormalities should include a differential diagnosis of MZ twinning, and a zygosity test is necessary under such a circumstance.<br />Competing Interests: Declaration of competing interest The authors have no conflicts of interest relevant to this article.<br /> (Copyright © 2020. Published by Elsevier B.V.)
- Subjects :
- Adult
Diagnosis, Differential
Diseases in Twins embryology
Diseases in Twins genetics
Female
Genetic Markers genetics
Humans
Hydronephrosis embryology
Hydronephrosis genetics
Hydrops Fetalis genetics
Infant, Newborn
Live Birth genetics
Lymphangioma, Cystic embryology
Lymphangioma, Cystic genetics
Male
Pregnancy
Pregnancy Reduction, Multifetal methods
Amniocentesis
Diseases in Twins diagnosis
Hydronephrosis diagnosis
Hydrops Fetalis diagnosis
Lymphangioma, Cystic diagnosis
Twins, Monozygotic genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1875-6263
- Volume :
- 59
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Taiwanese journal of obstetrics & gynecology
- Publication Type :
- Report
- Accession number :
- 33218418
- Full Text :
- https://doi.org/10.1016/j.tjog.2020.09.025