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Comprehensive characterization of the tumor microenvironment for assessing immunotherapy outcome in patients with head and neck squamous cell carcinoma.
- Source :
-
Aging [Aging (Albany NY)] 2020 Nov 18; Vol. 12 (22), pp. 22509-22526. Date of Electronic Publication: 2020 Nov 18. - Publication Year :
- 2020
-
Abstract
- The tumor microenvironment (TME) constitutes a complex milieu of cells and cytokines that maintain equilibrium between tumor progression and prognosis. However, comprehensive analysis of the TME and its clinical significance in head and neck squamous cell carcinoma (HNSCC) remains to be unreported. In this study, based on large-scale RNA sequencing data pertaining to single nucleotide variants (SNVs) and copy number variations (CNVs) in HNSCC patients from The Cancer Genome Atlas database, we analysed subpopulations of infiltrating immune cells and evaluated the role of TME infiltration pattern (TME score) in assessing immunotherapy outcome. TME signature genes involved in several inflammation and immunity signalling pathways were observed in the TME score subtype, which were considered immunosuppressive and potentially responsible for significantly worse prognosis. In comparison with SNV- and CNV-mediated tumor mutation burden, TME score can significantly differentiate between high- and low-risk HNSCC and predict immunotherapy outcome. Our data provide clarity on the comprehensive landscape of interactions between clinical characteristics of HNSCC and tumor-infiltrating immune cells. TME score seems to be a useful biomarker that can predict immunotherapy outcome in HNSCC patients.
- Subjects :
- Databases, Genetic
Gene Dosage
Gene Expression Profiling
Gene Regulatory Networks
Head and Neck Neoplasms genetics
Head and Neck Neoplasms immunology
Humans
Mutation
Predictive Value of Tests
RNA-Seq
Squamous Cell Carcinoma of Head and Neck genetics
Squamous Cell Carcinoma of Head and Neck immunology
Transcriptome
Treatment Outcome
Biomarkers, Tumor genetics
Head and Neck Neoplasms therapy
Immunotherapy
Squamous Cell Carcinoma of Head and Neck therapy
Tumor Microenvironment
Subjects
Details
- Language :
- English
- ISSN :
- 1945-4589
- Volume :
- 12
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Aging
- Publication Type :
- Academic Journal
- Accession number :
- 33216727
- Full Text :
- https://doi.org/10.18632/aging.103460