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Selected updates in molecular and genomic pathology of esophageal cancer.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Dec; Vol. 1482 (1), pp. 225-235. Date of Electronic Publication: 2020 Nov 20. - Publication Year :
- 2020
-
Abstract
- Recent years have seen rapid advances in the field of molecular and genomic pathology that have not only improved understanding of esophageal carcinogenesis and tumor immune environment in general but also have reshaped pathology practice and clinical management. In this article, we provide updates on three topics (1) human epidermal growth factor receptor 2, the first and most important biomarker in targeted therapy of esophageal cancer; (2) programmed death 1/programmed death ligand 1, recent biomarkers that have shown promise in treating both esophageal adenocarcinoma and esophageal squamous cell carcinoma; and (3) human papillomavirus involvement in esophageal carcinogenesis, one of the most debated topics in the field, discussed here with a renewed understanding from recent genomic and molecular data.<br /> (© 2020 New York Academy of Sciences.)
- Subjects :
- Adenocarcinoma drug therapy
Adenocarcinoma genetics
Alphapapillomavirus pathogenicity
Antineoplastic Agents, Immunological therapeutic use
B7-H1 Antigen genetics
ErbB Receptors antagonists & inhibitors
Esophageal Neoplasms drug therapy
Esophageal Neoplasms genetics
Esophageal Squamous Cell Carcinoma drug therapy
Esophageal Squamous Cell Carcinoma genetics
Humans
Lapatinib therapeutic use
Papillomavirus Infections pathology
Protein Kinase Inhibitors therapeutic use
Receptor, ErbB-2 antagonists & inhibitors
Receptor, ErbB-2 genetics
Trastuzumab therapeutic use
Adenocarcinoma pathology
B7-H1 Antigen metabolism
Esophageal Neoplasms pathology
Esophageal Squamous Cell Carcinoma pathology
Receptor, ErbB-2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1749-6632
- Volume :
- 1482
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33215736
- Full Text :
- https://doi.org/10.1111/nyas.14527