First international meeting of early career investigators: Current opportunities, challenges and horizon in critical care nutrition research.

Background: Appropriate nutritional support is a key component of care for critically ill patients. While malnutrition increases complications, impacting long term outcomes and healthcare-related costs, uncertainties persist regarding optimal provision of nutritional support in this setting.
Methods: An international group of healthcare providers (HCPs) from critical care specialties and nutrition researchers convened to identify knowledge gaps and learnings from studies in critical care nutrition. Clinical research needs were identified in order to better inform future nutrition practices.
Results: Challenges in critical care nutrition arise, in part, from inconsistent outcomes in several large-scale studies regarding the optimal amount of calories and protein to prescribe, the optimal time to initiate nutritional support and the role of parental nutrition to support critically ill patients. Furthermore, there is uncertainty on how best to identify patients at nutritional risk, and the appropriate outcome measures for ICU nutrition studies. Given HCPs have a suboptimal evidence base to inform the nutritional management of critically ill patients, further well-designed clinical trials capturing clinically relevant endpoints are needed to address these knowledge gaps.
Conclusions: The identified aspects for future research could be addressed in studies designed and conducted in collaboration with an international team of interdisciplinary nutrition experts. The aim of this collaboration is to address the unmet need for robust clinical data needed to develop high-quality evidence-based nutritional intervention recommendations to better inform the future management of critically ill patients.
Competing Interests: Declaration of Competing Interest All authors received financial support from Fresenius Kabi Deutschland GmbH to attend the 4-day focus group meeting on which this paper is based. CS received speakers fees from Baxter, Fresenius Kabi and financial support from Fresenius Kabi for a clinical study and research grant from Baxter Healthcare. RvG received an unrestricted research grant from Fresenius-Kabi and competitive research awards funded by Astellas and Nutricia. JJ has no other conflict of interest related to this article. MGV has no other conflict of interest related to this article. FGDG has no other conflict of interest related to this article. SC has no other conflict of interest related to this article. SW has no other conflict of interest related to this article. AA received honoraria for lectures from Abbott, Nestle and Fresenius Kabi. TF has no other conflict of interest related to this article. RM received honoraria for lectures from Fresenius Kabi. MB receives honoraria for lectures from Nutritional Industry (Abbott, Baxter, Fresenius Kai internation) Nestlé international.
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