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From angiotensin-converting enzyme 2 disruption to thromboinflammatory microvascular disease: A paradigm drawn from COVID-19.
- Source :
-
International journal of cardiology [Int J Cardiol] 2021 Mar 01; Vol. 326, pp. 243-247. Date of Electronic Publication: 2020 Nov 10. - Publication Year :
- 2021
-
Abstract
- We concisely review clinical, autopsy, experimental and molecular data of 2019 coronavirus disease (COVID-19). Angiotensin-converting enzyme 2 disruption and thromboinflammatory microangiopathy emerge as distinctive features. Briefly, entry of the virus into microvessels can profoundly disrupt the local renin-angiotensin system, cause endothelial injury, activate the complement cascade and induce powerful thromboinflammatory reactions, involving, in particular, von Willebrand factor, that, if widespread, may lead to microvascular plugging, ischemia and, ultimately, organ failure. We believe the current COVID-19 data consolidate a widely unrecognised paradigm of potentially fatal thromboinflammatory microvascular disease.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- COVID-19 diagnosis
COVID-19 epidemiology
Humans
Microvessels pathology
Renin-Angiotensin System physiology
Thrombosis diagnosis
Thrombosis epidemiology
Angiotensin-Converting Enzyme 2 metabolism
COVID-19 metabolism
Inflammation Mediators metabolism
Microvessels metabolism
Thrombosis metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 326
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 33181158
- Full Text :
- https://doi.org/10.1016/j.ijcard.2020.11.016