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Role of Mitochondria in Cancer Immune Evasion and Potential Therapeutic Approaches.
- Source :
-
Frontiers in immunology [Front Immunol] 2020 Oct 16; Vol. 11, pp. 573326. Date of Electronic Publication: 2020 Oct 16 (Print Publication: 2020). - Publication Year :
- 2020
-
Abstract
- The role of mitochondria in cancer formation and progression has been studied extensively, but much remains to be understood about this complex relationship. Mitochondria regulate many processes that are known to be altered in cancer cells, from metabolism to oxidative stress to apoptosis. Here, we review the evolving understanding of the role of mitochondria in cancer cells, and highlight key evidence supporting the role of mitochondria in cancer immune evasion and the effects of mitochondria-targeted antitumor therapy. Also considered is how knowledge of the role of mitochondria in cancer can be used to design and improve cancer therapies, particularly immunotherapy and radiation therapy. We further offer critical insights into the mechanisms by which mitochondria influence tumor immune responses, not only in cancer cells but also in immune cells. Given the central role of mitochondria in the complex interactions between cancer and the immune system, high priority should be placed on developing rational strategies to address mitochondria as potential targets in future preclinical and clinical studies. We believe that targeting mitochondria may provide additional opportunities in the development of novel antitumor therapeutics.<br /> (Copyright © 2020 Klein, He, Younes, Barsoumian, Chen, Ozgen, Mosaffa, Patel, Gu, Novaes, Narayanan, Cortez and Welsh.)
- Subjects :
- Animals
Humans
Immune Checkpoint Inhibitors therapeutic use
Immunotherapy, Adoptive
Lymphocytes, Tumor-Infiltrating immunology
Lymphocytes, Tumor-Infiltrating metabolism
Mitochondria drug effects
Mitochondria pathology
Mitochondria radiation effects
Molecular Targeted Therapy
Neoplasms immunology
Neoplasms pathology
Neoplasms therapy
Signal Transduction
T-Lymphocytes immunology
T-Lymphocytes metabolism
Tumor Hypoxia
Tumor Microenvironment
Tumor-Associated Macrophages immunology
Tumor-Associated Macrophages metabolism
Energy Metabolism drug effects
Energy Metabolism radiation effects
Mitochondria metabolism
Neoplasms metabolism
Tumor Escape drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 33178201
- Full Text :
- https://doi.org/10.3389/fimmu.2020.573326