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Epicardial Adipose Tissue and IL-13 Response to Myocardial Injury Drives Left Ventricular Remodeling After ST Elevation Myocardial Infarction.
- Source :
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Frontiers in physiology [Front Physiol] 2020 Oct 15; Vol. 11, pp. 575181. Date of Electronic Publication: 2020 Oct 15 (Print Publication: 2020). - Publication Year :
- 2020
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Abstract
- Introduction: Left ventricular (LV) remodeling after ST-segment elevation myocardial infarction (STEMI) is explained only in part by the infarct size, and the inter-patient variability may be ascribed to different inflammatory response to myocardial injury. Epicardial adipose tissue (EAT) is a source of inflammatory mediators which directly modulates the myocardium. EAT increase is associated to several cardiovascular diseases; however, its response to myocardial injury is currently unknown. Among inflammatory mediators, IL-13 seems to play protective role in LV regeneration, but its variations after STEMI have not been described yet. Purpose: In the present study we analyzed the association between infarct-related changes of EAT and IL-13 in post-STEMI LV remodeling.<br />Methods: We enrolled 100 patients with STEMI undergoing primary angioplasty. At the enrolment (T0) and after 3 months (T1), we measured EAT thickness by echocardiography and circulating levels of IL-13 by ELISA.<br />Results: At T1, the 60% of patients displayed increased EAT thickness (ΔEAT > 0). ΔEAT was directly associated to LV end-diastolic volume ( r = 0.42; p = 0.014), LV end-systolic volume ( r = 0.42; p = 0.013) and worse LV ejection fraction (LVEF) at T1 ( r = -0.44; p = 0.0094), independently of the infarct size. In the overall population IL-13 levels significantly decreased at T1 ( p = 0.0002). The ΔIL-13 was directly associated to ΔLVEF ( r = 0.42; p = 0.017) and inversely related to ΔEAT ( r = -0.51; p = 0.022), thus suggesting a protective role for IL-13.<br />Conclusion: The variability of STEMI-induced "inflammatory response" may be associated to the post-infarct LV remodeling. ΔEAT thickness and ΔIL-13 levels could be novel prognostic markers in STEMI patients.<br /> (Copyright © 2020 Parisi, Cabaro, D’Esposito, Petraglia, Conte, Campana, Gerundo, Abitabile, Tuccillo, Accadia, Comentale, Pilato, Sansone, Leosco and Formisano.)
Details
- Language :
- English
- ISSN :
- 1664-042X
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Frontiers in physiology
- Publication Type :
- Academic Journal
- Accession number :
- 33178043
- Full Text :
- https://doi.org/10.3389/fphys.2020.575181