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Design and In Vitro Characterization of Orally Disintegrating Modified Release Tablets of Naproxen Sodium.
- Source :
-
Turkish journal of pharmaceutical sciences [Turk J Pharm Sci] 2020 Oct; Vol. 17 (5), pp. 486-491. Date of Electronic Publication: 2020 Oct 30. - Publication Year :
- 2020
-
Abstract
- Objectives: The aim of this study was to prepare orally disintegrating, slow release tablets of naproxen sodium for prompt onset and sustained action required in many types of acute pain.<br />Materials and Methods: Tablet formulations containing varying concentrations of croscarmellose sodium (a superdisintegrant) and Soluplus <superscript>®</superscript> (as release modifier) were prepared by wet granulation method using a single punch tablet machine. The prepared granules were evaluated for their bulk properties and the tablets were evaluated for hardness, disintegration time, and drug release profiles.<br />Results: The results showed that the granules so prepared have good flow and compressional properties. A disintegration time of tablets <30 s was achieved by selecting an optimum concentration of croscarmellose sodium. The drug release from the tablets was sustained for 2 h by incorporating a suitable amount of Soluplus <superscript>®</superscript> .<br />Conclusion: This study examined the use of Soluplus <superscript>®</superscript> (a novel solubilizer) for the first time as a release modifier of API from tablets.<br />Competing Interests: Conflicts of interest: No conflict of interest was declared by the authors. The authors alone are responsible for the content and writing of the paper.<br /> (©Copyright 2020 Turk J Pharm Sci, Published by Galenos Publishing House.)
Details
- Language :
- English
- ISSN :
- 2148-6247
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Turkish journal of pharmaceutical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33177928
- Full Text :
- https://doi.org/10.4274/tjps.galenos.2019.24445