Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis.

Authors :: Leavitt T
Hu MS
Borrelli MR
Januszyk M
Garcia JT
Ransom RC
Mascharak S
desJardins-Park HE
Litzenburger UM
Walmsley GG
Marshall CD
Moore AL
Duoto B
Adem S
Foster DS
Salhotra A
Shen AH
Griffin M
Shen EZ
Barnes LA
Zielins ER
Maan ZN
Wei Y
Chan CKF
Wan DC
Lorenz HP
Chang HY
Gurtner GC
Longaker MT
Source :: Cell reports [Cell Rep] 2020 Nov 10; Vol. 33 (6), pp. 108356.
Publication Year :: 2020
Abstract: Fibroblast heterogeneity has been shown within the unwounded mouse dorsal dermis, with fibroblast subpopulations being identified according to anatomical location and embryonic lineage. Using lineage tracing, we demonstrate that paired related homeobox 1 (Prrx1)-expressing fibroblasts are responsible for acute and chronic fibroses in the ventral dermis. Single-cell transcriptomics further corroborated the inherent fibrotic characteristics of Prrx1 fibroblasts during wound repair. In summary, we identify and characterize a fibroblast subpopulation in the mouse ventral dermis with intrinsic scar-forming potential.<br />Competing Interests: Declaration of Interests H.Y.C. is a co-founder of Accent Therapeutics and Boundless Bio and an advisor to 10x Genomics, Arsenal Bioscience, and Spring Discovery.<br /> (Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.)