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Multisystem Inflammatory Syndrome in Children Related to COVID-19: the First Case in Korea.
- Source :
-
Journal of Korean medical science [J Korean Med Sci] 2020 Nov 09; Vol. 35 (43), pp. e391. Date of Electronic Publication: 2020 Nov 09. - Publication Year :
- 2020
-
Abstract
- Since mid-April 2020, cases of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease 2019 that mimics Kawasaki disease (KD) have been reported in Europe and North America. However, no cases have been reported in Korea. We describe an 11-year old boy with fever, abdominal pain, and diarrhea who developed hypotension requiring inotropes in intensive care unit. His blood test revealed elevated inflammatory markers, thrombocytopenia, hypoalbuminemia, and coagulopathy. Afterward, he developed signs of KD such as conjunctival injection, strawberry tongue, cracked lip, and coronary artery dilatation, and parenchymal consolidation without respiratory symptoms. Microbiological tests were all negative including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription polymerase chain reaction. However, serum immunoglobulin G against SARS-CoV-2 was positive in repeated tests using enzyme-linked immunosorbent assay and fluorescent immunoassay. He was recovered well after intravenous immunoglobulin administration and discharged without complication on hospital day 13. We report the first Korean child who met all the criteria of MIS-C with features of incomplete KD or KD shock syndrome.<br />Competing Interests: The authors have no potential conflicts of interest to disclose.<br /> (© 2020 The Korean Academy of Medical Sciences.)
- Subjects :
- Abdomen diagnostic imaging
Antibodies, Viral blood
Betacoronavirus genetics
Betacoronavirus immunology
COVID-19
Child
Coronavirus Infections complications
Coronavirus Infections virology
Humans
Immunoglobulins, Intravenous administration & dosage
Male
Mucocutaneous Lymph Node Syndrome pathology
Pandemics
Pneumonia, Viral complications
Pneumonia, Viral virology
SARS-CoV-2
Systemic Inflammatory Response Syndrome complications
Thorax diagnostic imaging
Tomography, X-Ray Computed
Ultrasonography
Coronavirus Infections pathology
Pneumonia, Viral pathology
Systemic Inflammatory Response Syndrome diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1598-6357
- Volume :
- 35
- Issue :
- 43
- Database :
- MEDLINE
- Journal :
- Journal of Korean medical science
- Publication Type :
- Report
- Accession number :
- 33169560
- Full Text :
- https://doi.org/10.3346/jkms.2020.35.e391