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Device related thrombus after left atrial appendage closure: State of the art.
- Source :
-
Pacing and clinical electrophysiology : PACE [Pacing Clin Electrophysiol] 2021 Jul; Vol. 44 (7), pp. 1253-1258. Date of Electronic Publication: 2020 Dec 10. - Publication Year :
- 2021
-
Abstract
- Atrial fibrillation (AF), the most common arrhythmia, is a major cause of stroke and systemic embolism. Patients with AF are at higher risk of stroke with the left atrial appendage (LAA) being the most common site for thrombus formation. Although oral anticoagulation (OAC) remains the standard of care for stroke prevention in AF patients, there are still several limitations, including increased risk of bleeding and noncompliance. LAA closure (LAAC) has been found to be non-inferior to OAC in preventing all-cause strokes and systemic embolisms in randomized clinical trials, and is increasingly performed for stroke prevention in patients with nonvalvular AF (NVAF). However, device-related thrombus (DRT) after LAAC and a potentially increased risk of stroke related to DRT were observed in several registered studies, and attract wide concern. This review provides a comprehensive update on the incidence, mechanism, risk factors, prevention, diagnosis, and treatment of DRT after LAAC in patients with NVAF.<br /> (© 2020 Wiley Periodicals LLC.)
- Subjects :
- Cardiac Surgical Procedures instrumentation
Humans
Postoperative Complications diagnosis
Postoperative Complications epidemiology
Postoperative Complications therapy
Atrial Appendage surgery
Atrial Fibrillation surgery
Postoperative Complications etiology
Prostheses and Implants adverse effects
Thrombosis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1540-8159
- Volume :
- 44
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Pacing and clinical electrophysiology : PACE
- Publication Type :
- Academic Journal
- Accession number :
- 33165978
- Full Text :
- https://doi.org/10.1111/pace.14122