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Impact of concurrent diabetes on periodontal health in patients with acromegaly.
- Source :
-
Scientific reports [Sci Rep] 2020 Nov 05; Vol. 10 (1), pp. 19170. Date of Electronic Publication: 2020 Nov 05. - Publication Year :
- 2020
-
Abstract
- Previous studies have suggested excess GH/IGF1 secretion in patients with acromegaly is protective for periodontal health. Diabetes is prevalent comorbidity in patients of acromegaly and is associated with worsening of periodontal disease. The present study evaluates the periodontal health and cytokines status in treatment-naive active acromegaly patients with and without diabetes. Eleven patients, each of acromegaly with and without diabetes and 20 healthy controls were enrolled. Periodontal parameters were assessed. GCF and blood samples for IL-6, TGF-β1, and PDGF were obtained. Serum GH, IGF1, HbA1c, pituitary hormones and MRI sella were performed in patients with acromegaly. There was no significant difference in periodontal status of patients with acromegaly and healthy controls. However, a significant increase in serum IL-6 (p = 0.019) and TGF-β1 (p = 0.025) levels in patients with acromegaly was observed and all patients had concurrent hypogonadism. Nevertheless, the patients with acromegaly having diabetes had modestly higher CAL and PD and serum IL-6 levels (p = 0.051), but it could not exert adverse effects on periodontal health in presence of GH/IGF1 excess. GH/IGF1 excess did not exert a protective effect on periodontal status in acromegaly, possibly due to concurrent hypogonadism and opposing cytokines; however, it could mask the ill-effects of diabetes on periodontal health.
- Subjects :
- Acromegaly blood
Acromegaly diagnostic imaging
Adult
Diabetes Mellitus, Type 2 blood
Diabetes Mellitus, Type 2 diagnostic imaging
Female
Follicle Stimulating Hormone blood
Glycated Hemoglobin metabolism
Human Growth Hormone blood
Humans
Insulin-Like Growth Factor I metabolism
Interleukin-6 blood
Luteinizing Hormone blood
Magnetic Resonance Imaging
Male
Middle Aged
Pituitary Gland diagnostic imaging
Platelet-Derived Growth Factor metabolism
Prolactin blood
Transforming Growth Factor beta1 blood
Acromegaly complications
Diabetes Mellitus, Type 2 complications
Oral Health
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 33154456
- Full Text :
- https://doi.org/10.1038/s41598-020-76067-5