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Immune dyscrasia in adult growth hormone deficiency: Evaluation of hemolytic complement activity (CH50) and IgG subclasses.
- Source :
-
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2020 Nov; Vol. 131, pp. 110757. Date of Electronic Publication: 2020 Sep 19. - Publication Year :
- 2020
-
Abstract
- CH50 is a screening assay for the activation of the classical complement pathway, the immunoglobulins-mediated one, activated in several inflammatory diseases. Adult growth hormone deficiency (aGHD) is recognized as a chronic inflammatory condition, although poorly evaluated under the profile of inflammatory biomarkers. The aim of this case-control observational study is to analyze CH50 and immunoglobulins G (IgG) subclasses production in aGHD, comparing this condition to healthy controls. 38 subjects were included and divided as follows: aGHD (n = 18, 6 females and 12 males); healthy controls (n = 20, 10 females and 10 males). GHD was diagnosed with dynamic test using Growth Hormone-Releasing Hormone (GHRH 50 μg i.v. + arginine 0,5 g/Kg), with a peak GH response < 9 μg/L when BMI was <30 kg/m <superscript>2</superscript> or < 4 μg/L when BMI was >30 kg/m <superscript>2</superscript> . The two groups were evaluated for hormonal and metabolic parameters, CH50 and IgG subtypes. IgG1 and IgG2 were significantly higher in controls than in aGHD, while IgG3 and IgG4 showed a trend to higher levels in controls, although not significant. Furthermore, CH50 levels were significantly higher in aGHD. These data substantiate the hypothesis of a dyscrasia in IgG subclasses production in aGHD. As IgG levels decrease, CH50 levels do not.<br /> (Copyright © 2020. Published by Elsevier Masson SAS.)
- Subjects :
- Adult
Aged
Arginine administration & dosage
Body Mass Index
Case-Control Studies
Complement Hemolytic Activity Assay
Female
Growth Hormone-Releasing Hormone administration & dosage
Human Growth Hormone immunology
Humans
Male
Middle Aged
Complement System Proteins immunology
Human Growth Hormone deficiency
Immunoglobulin G immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1950-6007
- Volume :
- 131
- Database :
- MEDLINE
- Journal :
- Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- Publication Type :
- Academic Journal
- Accession number :
- 33152922
- Full Text :
- https://doi.org/10.1016/j.biopha.2020.110757