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Modified poly(3-hydroxybutyrate)-based scaffolds in tissue engineering applications: A review.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jan 01; Vol. 166, pp. 986-998. Date of Electronic Publication: 2020 Nov 02. - Publication Year :
- 2021
-
Abstract
- As a member of the polyhydroxyalkanoate (PHAs) family, Poly(3-hydroxybutyrate) (PHB) has attracted much attention for a variety of medical applications because of its desirable properties such as high biocompatibility, nontoxic degradation products and high mechanical strength in comparison to other polymers in different fields including tissue engineering. There are different approaches such as making PHB alloy scaffolds, using PHB as a coating for ceramic-based scaffolds and producing composite scaffolds by using a mixture of PHB with ceramic particles utilized to improve hydrophobicity, degradation rate and brittleness. In this review, different applications of PHB, its alloys and composites in tissue engineering are explained based on the common methods of fabrication such as polymeric sponge replication, electrospinning and salt leaching.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Ceramics chemistry
Humans
Nanocomposites chemistry
Neurons cytology
Neurons drug effects
Osteoblasts cytology
Osteoblasts drug effects
Prohibitins
Skin cytology
Skin drug effects
Tissue Scaffolds adverse effects
Hydroxybutyrates chemistry
Polyesters chemistry
Tissue Engineering methods
Tissue Scaffolds chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 166
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 33152357
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2020.10.255