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Modified poly(3-hydroxybutyrate)-based scaffolds in tissue engineering applications: A review.

Authors :
Soleymani Eil Bakhtiari S
Karbasi S
Toloue EB
Source :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Jan 01; Vol. 166, pp. 986-998. Date of Electronic Publication: 2020 Nov 02.
Publication Year :
2021

Abstract

As a member of the polyhydroxyalkanoate (PHAs) family, Poly(3-hydroxybutyrate) (PHB) has attracted much attention for a variety of medical applications because of its desirable properties such as high biocompatibility, nontoxic degradation products and high mechanical strength in comparison to other polymers in different fields including tissue engineering. There are different approaches such as making PHB alloy scaffolds, using PHB as a coating for ceramic-based scaffolds and producing composite scaffolds by using a mixture of PHB with ceramic particles utilized to improve hydrophobicity, degradation rate and brittleness. In this review, different applications of PHB, its alloys and composites in tissue engineering are explained based on the common methods of fabrication such as polymeric sponge replication, electrospinning and salt leaching.<br /> (Copyright © 2020 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0003
Volume :
166
Database :
MEDLINE
Journal :
International journal of biological macromolecules
Publication Type :
Academic Journal
Accession number :
33152357
Full Text :
https://doi.org/10.1016/j.ijbiomac.2020.10.255