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Cut-off value of serum homocysteine in relation to increase of coronary artery calcification.
- Source :
-
Journal of investigative medicine : the official publication of the American Federation for Clinical Research [J Investig Med] 2021 Feb; Vol. 69 (2), pp. 345-350. Date of Electronic Publication: 2020 Nov 04. - Publication Year :
- 2021
-
Abstract
- A recent study reported that coronary artery calcification (CAC) and serum homocysteine were well associated; however, no report is available for the cut-off value of serum homocysteine according to increase of coronary-artery calcification volume score (CVS). The data of 469 out of 777 subjects in 1 health promotion center located in Seoul were selected after exclusion of the missing data of serum homocysteine and CVS. CVS was categorized into 2 groups: CVS=0 and CVS>0. Serum homocysteine according to the CVS groups was compared, and the cut-off value of serum homocysteine according to the increase of CVS (>0) was calculated using the receiver operating characteristic curve. Mean age was 54.5 years and the proportion of females was 22.2%. Mean serum homocysteine concentration and CVS were 11.2 μmol/L and 50.4, respectively. After adjustments for age and sex, serum homocysteine was associated with CVS (r=0.167, p=0.001), and Log(Homocysteine) also showed a significant difference according to the CVS groups. The cut-off value of serum homocysteine according to the increase of CVS (>0) was 9.45 μmol/L (area under the curve=0.569 (95% CI 0.512 to 0.625), p=0.015). The cut-off value of serum homocysteine was 9.45 μmol/L according to the increase of coronary-artery CVS.<br />Competing Interests: Competing interests: None declared.<br /> (© American Federation for Medical Research 2021. Re-use permitted under CC BY-NC. No commercial re-use. Published by BMJ.)
Details
- Language :
- English
- ISSN :
- 1708-8267
- Volume :
- 69
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of investigative medicine : the official publication of the American Federation for Clinical Research
- Publication Type :
- Academic Journal
- Accession number :
- 33148632
- Full Text :
- https://doi.org/10.1136/jim-2020-001478