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Chemical Space Exploration of Oxetanes.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 02; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 02. - Publication Year :
- 2020
-
Abstract
- This paper focuses on new derivatives bearing an oxetane group to extend accessible chemical space for further identification of kinase inhibitors. The ability to modulate kinase activity represents an important therapeutic strategy for the treatment of human illnesses. Known as a nonclassical isoster of the carbonyl group, due to its high polarity and great ability to function as an acceptor of hydrogen bond, oxetane seems to be an attractive and underexplored structural motif in medicinal chemistry.
- Subjects :
- Autoimmune Diseases drug therapy
Chemistry, Organic
Electrons
Ethers, Cyclic chemistry
Humans
Hydrogen Bonding
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Models, Chemical
Phenol chemistry
Stereoisomerism
Structure-Activity Relationship
Ethers, Cyclic pharmacology
Molecular Structure
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 21
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33147789
- Full Text :
- https://doi.org/10.3390/ijms21218199