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The effects of Elaeagnus angustifolia L. on lipid and glycaemic profiles and cardiovascular function in menopausal women: A double-blind, randomized, placebo-controlled study.
- Source :
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International journal of clinical practice [Int J Clin Pract] 2021 Apr; Vol. 75 (4), pp. e13812. Date of Electronic Publication: 2020 Dec 02. - Publication Year :
- 2021
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Abstract
- Aims: The reduced production of ovarian hormones is considered to be the cause of an increase in the incidence of heart disease in women after menopause. Phytoestrogens are found in various herbal sources and are considered as an alternative to hormone therapy because of structural similarity with oestrogen. Elaeagnus angustifolia L., known as Senjed in Persian, is used in Iranian traditional medicine with various medicinal properties, contains valuable compounds, including two types of phytoestrogens. The aim of the present study was to investigate the efficacy of E. angustifolia fruit on the cardiovascular function, lipid and glycaemic profiles in postmenopausal women.<br />Methods: In this double-blind placebo-controlled clinical trial, 58 postmenopausal women were randomly assigned into two experimental groups of medicinal herb (15 g/day of the whole E. angustifolia fruit powder) and placebo (15 g/day of isomalt + corn starch). Before the trial and after 10 weeks of the treatment, cardiovascular function (heart rate, blood pressure), serum glycaemic profile (fasting blood glucose; glycated haemoglobin, HbA1C), insulin and lipid profile (total cholesterol, TC; triglyceride, TG; LDL-C and HDL-C) were measured.<br />Results: Heart rate, and serum level of LDL-C and HDL-C significantly decreased after treatment with E. angustifolia. Changes in glycaemic profile were not clinically significant. In addition, some studied biochemical parameters significantly changed in the placebo group.<br />Conclusions: E. angustifolia was somewhat effective in improving cardiovascular function and lipid profile, as well as the overall health of postmenopausal women. However, the use of isomalt and corn starch in menopausal women needs further investigation.<br /> (© 2020 John Wiley & Sons Ltd.)
- Subjects :
- Double-Blind Method
Female
Humans
Iran
Lipids
Menopause
Blood Glucose
Elaeagnaceae
Subjects
Details
- Language :
- English
- ISSN :
- 1742-1241
- Volume :
- 75
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 33145864
- Full Text :
- https://doi.org/10.1111/ijcp.13812