Back to Search
Start Over
Case Fatality Rate Related to Microcephaly Congenital Zika Syndrome and Associated Factors: A Nationwide Retrospective Study in Brazil †.
- Source :
-
Viruses [Viruses] 2020 Oct 29; Vol. 12 (11). Date of Electronic Publication: 2020 Oct 29. - Publication Year :
- 2020
-
Abstract
- Background: The clinical manifestations of microcephaly/congenital Zika syndrome (microcephaly/CZS) have harmful consequences on the child's health, increasing vulnerability to childhood morbidity and mortality. This study analyzes the case fatality rate and child-maternal characteristics of cases and deaths related to microcephaly/CZS in Brazil, 2015-2017.<br />Methods: Population-based study developed by linkage of three information systems. We estimate frequencies of cases, deaths, case fatality rate related to microcephaly/CZS according to child and maternal characteristics and causes of death. Multivariate logistic regression models were applied.<br />Results: The microcephaly/CZS case fatality rate was 10% (95% CI 9.2-10.7). Death related to microcephaly/CZS was associated to moderate (OR = 2.15; 95% CI 1.63-2.83), and very low birth weight (OR = 3.77; 95% CI 2.20-6.46); late preterm births (OR = 1.65; 95% CI 1.21-2.23), Apgar < 7 at 1st (OR = 5.98; 95% CI 4.46-8.02) and 5th minutes (OR = 4.13; 95% CI 2.78-6.13), among others.<br />Conclusions: A high microcephaly/CZS case fatality rate and important factors associated with deaths related to this syndrome were observed. These results can alert health teams to these problems and increase awareness about the factors that may be associated with worse outcomes.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Adolescent
Adult
Brazil epidemiology
Female
Humans
Logistic Models
Male
Medical Records
Middle Aged
Pregnancy
Retrospective Studies
Risk Factors
Young Adult
Zika Virus Infection congenital
Zika Virus Infection epidemiology
Microcephaly mortality
Pregnancy Complications, Infectious virology
Zika Virus Infection mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1999-4915
- Volume :
- 12
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Viruses
- Publication Type :
- Academic Journal
- Accession number :
- 33138282
- Full Text :
- https://doi.org/10.3390/v12111228