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Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study.
- Source :
-
The American journal of medicine [Am J Med] 2021 Apr; Vol. 134 (4), pp. 526-534.e11. Date of Electronic Publication: 2020 Oct 29. - Publication Year :
- 2021
-
Abstract
- Background: A seroprevalence study can estimate the percentage of people with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies in the general population; however, most existing reports have used a convenience sample, which may bias their estimates.<br />Methods: We sought a representative sample of Connecticut residents, ages ≥18 years and residing in noncongregate settings, who completed a survey between June 4 and June 23, 2020, and underwent serology testing for SARS-CoV-2-specific immunoglobulin G (IgG) antibodies between June 10 and July 29, 2020. We also oversampled non-Hispanic black and Hispanic subpopulations. We estimated the seroprevalence of SARS-CoV-2-specific IgG antibodies and the prevalence of symptomatic illness and self-reported adherence to risk-mitigation behaviors among this population.<br />Results: Of the 567 respondents (mean age 50 [± 17] years; 53% women; 75% non-Hispanic white individuals) included at the state level, 23 respondents tested positive for SARS-CoV-2-specific antibodies, resulting in weighted seroprevalence of 4.0 (90% confidence interval [CI] 2.0-6.0). The weighted seroprevalence for the oversampled non-Hispanic black and Hispanic populations was 6.4% (90% CI 0.9-11.9) and 19.9% (90% CI 13.2-26.6), respectively. The majority of respondents at the state level reported following risk-mitigation behaviors: 73% avoided public places, 75% avoided gatherings of families or friends, and 97% wore a facemask, at least part of the time.<br />Conclusions: These estimates indicate that the vast majority of people in Connecticut lack antibodies against SARS-CoV-2, and there is variation by race and ethnicity. There is a need for continued adherence to risk-mitigation behaviors among Connecticut residents to prevent resurgence of COVID-19 in this region.<br /> (Copyright © 2020. Published by Elsevier Inc.)
- Subjects :
- Attitude to Health ethnology
Connecticut epidemiology
Ethnicity
Female
Humans
Male
Middle Aged
Needs Assessment
Prevalence
SARS-CoV-2 isolation & purification
Seroepidemiologic Studies
Antibodies, Viral blood
COVID-19 diagnosis
COVID-19 epidemiology
COVID-19 immunology
COVID-19 psychology
COVID-19 Serological Testing methods
COVID-19 Serological Testing statistics & numerical data
Immunoglobulin G blood
Risk Reduction Behavior
Subjects
Details
- Language :
- English
- ISSN :
- 1555-7162
- Volume :
- 134
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of medicine
- Publication Type :
- Academic Journal
- Accession number :
- 33130124
- Full Text :
- https://doi.org/10.1016/j.amjmed.2020.09.024