t(1;22)(p13;q13) Acute Megakaryoblastic Leukemia Complicated by Hepatic Fibrosis: Antifibrosis Therapy?

Authors :: Feng J
Leung AWK
Cheng FWT
Lam GKS
Chow TTW
Ng MHL
Chu WCW
Chan NPH
Li CK
Source :: Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2021 Nov 01; Vol. 43 (8), pp. e1164-e1167.
Publication Year :: 2021
Abstract: Background: There is no established effective treatment for patients with t(1;22)(p13;q13) acute megakaryoblastic leukemia (AMKL) and hepatic fibrosis.<br />Observation: Here we report the outcomes of 2 t(1;22)(p13;q13) AMKL patients with hepatic fibrosis. One patient died from liver failure despite the control of leukemia. The other patient was successfully treated with reduced-intensity chemotherapy and antifibrosis therapy with tretinoin and α-tocopheryl acetate, the hepatic fibrosis resolved and leukemia was in remission for 3 years.<br />Conclusions: Reduced-intensity chemotherapy plus antifibrosis therapy with tretinoin and α-tocopheryl acetate could be a treatment option for these patients with t(1;22)(p13;q13) AMKL and hepatic fibrosis.<br />Competing Interests: The authors declare no conflict of interest.<br /> (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)

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