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Self-Synthesizing Nanorods from Dynamic Combinatorial Libraries against Drug Resistant Cancer.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2021 Feb 08; Vol. 60 (6), pp. 3062-3070. Date of Electronic Publication: 2020 Dec 16. - Publication Year :
- 2021
-
Abstract
- Molecular self-assembly has been widely used to develop nanocarriers for drug delivery. However, most of them have unsatisfactory drug loading capacity (DLC) and the dilemma between stimuli-responsiveness and stability, stagnating their translational process. Herein, we overcame these drawbacks using dynamic combinatorial chemistry. A carrier molecule was spontaneously and quantitatively synthesized, aided by co-self-assembly with a template molecule and an anti-cancer drug doxorubicin (DOX) from a dynamic combinatorial library that was operated by disulfide exchange under thermodynamic control. The highly selective synthesis guaranteed a stable yet pH- and redox- responsive nanocarrier with a maximized DLC of 40.1 % and an enhanced drug potency to fight DOX resistance in vitro and in vivo. Our findings suggested that harnessing the interplay between synthesis and self-assembly in complex chemical systems could yield functional nanomaterials for advanced applications.<br /> (© 2020 Wiley-VCH GmbH.)
- Subjects :
- Animals
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Cell Line, Tumor
Cell Proliferation drug effects
Doxorubicin pharmacology
Doxorubicin therapeutic use
Drug Resistance, Neoplasm drug effects
Humans
Hydrogen-Ion Concentration
Mice
Mice, Nude
Neoplasms drug therapy
Neoplasms pathology
Oxidation-Reduction
Transplantation, Heterologous
Antineoplastic Agents chemistry
Doxorubicin chemistry
Drug Carriers chemistry
Nanotubes chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 60
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 33112477
- Full Text :
- https://doi.org/10.1002/anie.202010937