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A new role for histone demethylases in the maintenance of plant genome integrity.
- Source :
-
ELife [Elife] 2020 Oct 27; Vol. 9. Date of Electronic Publication: 2020 Oct 27. - Publication Year :
- 2020
-
Abstract
- Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis , EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction.<br />Competing Interests: JA, MN, JR, SO, YH, AD, KO, DM, FA, CR, AW, JD, MU, DL, RS, MB, JG No competing interests declared, DW Senior editor, eLife<br /> (© 2020, Antunez-Sanchez et al.)
- Subjects :
- Arabidopsis genetics
Arabidopsis growth & development
Arabidopsis metabolism
Arabidopsis Proteins genetics
Gene Expression Regulation, Plant
Histones metabolism
Jumonji Domain-Containing Histone Demethylases genetics
Polycomb Repressive Complex 2 genetics
Polycomb Repressive Complex 2 metabolism
Transcription Factors genetics
Arabidopsis enzymology
Arabidopsis Proteins metabolism
Genome, Plant
Jumonji Domain-Containing Histone Demethylases metabolism
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2050-084X
- Volume :
- 9
- Database :
- MEDLINE
- Journal :
- ELife
- Publication Type :
- Academic Journal
- Accession number :
- 33107825
- Full Text :
- https://doi.org/10.7554/eLife.58533