Deciphering the Biosynthetic Mechanism of Pelletierine in Lycopodium Alkaloid Biosynthesis.

Authors :: Wang J
Zhang ZK
Jiang FF
Qi BW
Ding N
Hnin SYY
Liu X
Li J
Wang XH
Tu PF
Abe I
Morita H
Shi SP
Source :: Organic letters [Org Lett] 2020 Nov 06; Vol. 22 (21), pp. 8725-8729. Date of Electronic Publication: 2020 Oct 26.
Publication Year :: 2020
Abstract: Pelletierine, a proposed building block of Lycopodium alkaloids (LAs), was demonstrated to be synthesized via the non-enzymatic Mannich-like condensation of Δ <superscript>1</superscript> -piperideine and 3-oxoglutaric acid produced by two new type III PKSs (HsPKS4 and PcPKS1) characterized from Huperzia serrata and Phlegmariurus cryptomerianus , respectively. The findings provide new insights for further understanding the biosynthesis of LAs such as huperzine A.

Subjects :: Alkaloids chemistry
Stereoisomerism
Alkaloids biosynthesis
Lycopodium metabolism
Piperidines metabolism

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