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Human papillomavirus infection in esophageal squamous cell carcinoma and esophageal adenocarcinoma: a concise review.
- Source :
-
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2020 Dec; Vol. 1482 (1), pp. 36-48. Date of Electronic Publication: 2020 Oct 25. - Publication Year :
- 2020
-
Abstract
- The causal link between high-risk human papillomavirus (hr-HPV) infection and cervical, anogenital, and some oropharyngeal malignancies has been established by both molecular and epidemiological data. The association between HPV and esophageal squamous cell carcinoma (ESCC) remains controversial, as is the true prevalence of HPV infection in ESCC. The wide range in reported rates reflects variability in the primary literature, with some larger scale case-control studies suggesting the infection rates range from 0% to 78%. Interactions between HPV and the Barrett's metaplasia-dysplasia-carcinoma sequence have been explored, and these studies have shown some conflicting data. Overall, systematic reviews have reported the prevalence of HPV-positive DNA in esophageal adenocarcinoma patients of between 13% and 35%. Postulated reasons for discrepancies in HPV prevalence rates in esophageal cancer include variations in testing methodology and assay sensitivities; technical issues, including the lack of a gold-standard primer; types of specimens utilized (fresh-frozen versus formalin-fixed tissue); geographical variation; cross-contamination; and small sample sizes. Thus, efforts must be undertaken to (1) standardize HPV testing, ideally in a central laboratory and utilizing tests that detect viral transcriptional activity; (2) avoid cross-contamination; and (3) recruit large numbers of patients to accurately ascertain HPV rates in esophageal malignancy.<br /> (© 2020 New York Academy of Sciences.)
- Subjects :
- Adenocarcinoma virology
Adolescent
Adult
Aged
Alphapapillomavirus isolation & purification
Barrett Esophagus pathology
Esophageal Neoplasms virology
Esophageal Squamous Cell Carcinoma virology
Female
Humans
Male
Middle Aged
Papillomavirus Infections epidemiology
Young Adult
Adenocarcinoma pathology
Barrett Esophagus virology
Esophageal Neoplasms pathology
Esophageal Squamous Cell Carcinoma pathology
Papillomavirus Infections pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1749-6632
- Volume :
- 1482
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Annals of the New York Academy of Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 33103249
- Full Text :
- https://doi.org/10.1111/nyas.14509