Back to Search
Start Over
Induction of apoptosis and role of paclitaxel-loaded hyaluronic acid-crosslinked nanoparticles in the regulation of AKT and RhoA.
- Source :
-
Journal of advanced pharmaceutical technology & research [J Adv Pharm Technol Res] 2020 Jul-Sep; Vol. 11 (3), pp. 101-106. Date of Electronic Publication: 2020 Jul 14. - Publication Year :
- 2020
-
Abstract
- Cancer is a complex multifactorial disease and leading causes of death worldwide. Despite the development of many anticancer drugs, there is a reduced survival rate due to severe side effects. The nontargeted approach of convention drugs is one of the leading players in context to toxicity. Hyaluronan is a versatile bio-polymer and ligand of the receptor (CD44) on cancer cells. The MCF-7 and HT-29 cancer cell lines treated with hyaluronic acid-paclitaxel (HA-PTX) showed the distinguishing morphological features of apoptosis. Flow cytometric analysis showed that HA-PTX induces apoptosis as a significant mode of cell death. The activation level of tumor suppressor protein (p53) increased after PTX treatment in MCF-7, but no changes observed in HT-29 might be due to hereditary mutations. The lack of suppression in AKT and Rho A protein suggest the use of possible inhibitors in future studies which might could play a role in increasing the sensitivity of drug towards mutated cells line and reducing the possibilities for cancer cell survival, migration, and metastasis.<br />Competing Interests: There are no conflicts of interest.<br /> (Copyright: © 2020 Journal of Advanced Pharmaceutical Technology & Research.)
Details
- Language :
- English
- ISSN :
- 2231-4040
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of advanced pharmaceutical technology & research
- Publication Type :
- Academic Journal
- Accession number :
- 33102192
- Full Text :
- https://doi.org/10.4103/japtr.JAPTR_26_20