Experimental Modeling of Leprosy in BALB/c, BALB/c Nude, CBA, and C57BL/6ТNF -/- Mice.

Authors :: Karamova AE
Semenova VG
Verbenko DA
Obraztsova OA
Vanchugova KM
Nikonorov AA
Deryabin DG
Solomka VS
Kubanov AA
Source :: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2020 Oct; Vol. 169 (6), pp. 836-839. Date of Electronic Publication: 2020 Oct 24.
Publication Year :: 2020
Abstract: Leprosy was modeled in an experiment on BALB/c, BALB/cNude, CBA, and C57BL/6ТNF <superscript>-/-</superscript> mice using three Mycobacterium leprae strains obtained from patients with a diagnosis of A30 according to ICD-10 from different regions of the Russian Federation. Proliferation of M. leprae of the used strains showed a temporal-quantitative dependence on the used mouse line. CBA and BALB/cNude mice were optimal for strain R and BALB/c and BALB/cNude lines were optimal for strain I. BALB/cNude mice infected with strain I had low lifespan. M. leprae strain M showed low proliferation activity in BALB/cNude and C57BL/6ТNF <superscript>-/-</superscript> mice.

Full Text Access

Tools