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SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020.
- Source :
-
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [Euro Surveill] 2020 Oct; Vol. 25 (42). - Publication Year :
- 2020
-
Abstract
- SARS-CoV-2 IgG screening of 1,000 antenatal serum samples in the Oxford area, United Kingdom, between 14 April and 15 June 2020, yielded a 5.3% seroprevalence, mirroring contemporaneous regional data. Among the 53 positive samples, 39 showed in vitro neutralisation activity, correlating with IgG titre (Pearson's correlation p<0.0001). While SARS-CoV-2 seroprevalence in pregnancy cohorts could potentially inform population surveillance, clinical correlates of infection and immunity in pregnancy, and antenatal epidemiology evolution over time need further study.
- Subjects :
- Adolescent
Adult
COVID-19
Cohort Studies
Coronavirus Infections blood
England epidemiology
Enzyme-Linked Immunosorbent Assay
Female
Humans
Middle Aged
Pneumonia, Viral blood
Pregnancy
Prenatal Diagnosis
Prevalence
SARS-CoV-2
Seroepidemiologic Studies
Single-Blind Method
Young Adult
Antibodies, Neutralizing blood
Antibodies, Viral blood
Betacoronavirus immunology
Coronavirus Infections epidemiology
Immunoglobulin G blood
Pandemics
Pneumonia, Viral epidemiology
Population Surveillance
Pregnancy Complications, Infectious blood
Pregnancy Trimester, First blood
Subjects
Details
- Language :
- English
- ISSN :
- 1560-7917
- Volume :
- 25
- Issue :
- 42
- Database :
- MEDLINE
- Journal :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 33094717
- Full Text :
- https://doi.org/10.2807/1560-7917.ES.2020.25.41.2001721